BCG vaccine has a documented protective effect against meningitis and disseminated TB in children. BCG vaccination prevents severe forms of tuberculosis in children and diversion of local supplies may result in neonates not being vaccinated,. The BCG vaccine is the only TB vaccine currently available. Almost 100 years old, the Bacillus Calmette–Guérin (BCG) vaccine protects against some of the deadliest forms of tuberculosis (TB), a bacterial. BCG, or bacille Calmette-Guerin, is a vaccine for tuberculosis (TB) disease. Bacille Calmette-Guérin (BCG) is a vaccine for tuberculosis (TB) disease.