An inherited life-threatening disorder that damages the lungs and digestive system. Cystic fibrosis (CF) is an inherited disorder that causes severe damage to the lungs, digestive system and other organs in the body. Cystic fibrosis is a progressive, genetic disease that causes persistent lung infections and limits the ability to breathe over time. Cystic fibrosis is a complex, chronic disease that primarily affects the lungs and digestive system. Cystic fibrosis is a serious genetic condition that causes severe damage to the respiratory and digestive systems. Cystic fibrosis is an inherited disease characterized by the buildup of thick, sticky mucus that can damage many of the body's organs.