Marie-France Civit

Weight gain while you are taking Lyrica can be associated with higher doses and longer lengths of treatment. In studies, few patients (0.3%) stopped treatment due to weight gain.

Lyrica treatment may also cause peripheral edema (swelling of your hands, legs and feet), which can be associated with weight gain.

Weight gain was not associated with clinically important changes in blood pressure in short-term controlled studies, but the long-term effects of weight gain on heart safety due to Lyrica are unknown.

Patients with diabetes treated with Lyrica gained an average of 1.6 kg (3.5 lb) compared to 0.3 kg (0.66 lb) in the placebo-treated patients.

There was a wide range of weight changes among these patients with diabetes.

In controlled and open-label longer term studies, Lyrica does not appear to be linked with loss of blood sugar control (HbA1c) in patients with diabetes.

Weight gain and fluid retention are known side effects of the thiazolidinedione antidiabetic drug class. Higher frequencies of weight gain and peripheral edema were seen in diabetes patients taking both Lyrica and a thiazolidinedione medicine (examples: rosiglitazone or pioglitazone) when compared to patients taking either drug alone.

Use caution if you are taking Lyrica with a thiazolidinedione medicine, as the combination may worsen or lead to heart failure. Contact your doctor right away if you experience any of the symptoms:

Besides weight gain, other common side effects with Lyrica include:

Lyrica can also cause some serious side effects, such as:

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