Frédéric Haksar
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The causes and symptoms of connective tissue diseases are caused by gene defects vary as a result of what protein is abnormally produced by that defective gene.
Ehlers-Danlos syndrome (EDS) is caused by a collagen formation problem. EDS is actually a group of over 10 disorders, all characterized by:
Depending on the particular type of EDS, people may also have weak blood vessels, a curved spine, bleeding gums, or problems with the heart valves, lungs, or digestion. Symptoms range from mild to extremely severe.
Epidermolysis bullosa (EB) is caused by a gene mutation that makes skin more fragile. The skin of people with EB often blisters or tears at even the slightest bump or sometimes even just from clothing rubbing against it.
More than one type of EB can occur. Depending on the type, the genetic mutation affects how different proteins in your skin, such as keratin, laminin, or collagen, are made.
Some types of EB can affect the respiratory tract, the digestive tract, the bladder, or the muscles.
Marfan syndrome is caused by a defect in the connective tissue protein fibrillin. It affects the:
People with Marfan syndrome are often unusually tall and slender, have very long bones, and have thin fingers and toes. Sometimes people with Marfan syndrome have an enlarged segment of their aorta (aortic aneurysm), which can lead to fatal bursting (rupture).
Osteogenesis imperfecta is caused by gene mutations that affect the body’s ability to produce collagen. People with different gene defects that fall under this heading typically have:
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