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Ehlers-Danlos syndrome (EDS) is caused by a collagen formation problem. EDS is actually a group of over 10 disorders, all characterized by:

Depending on the particular type of EDS, people may also have weak blood vessels, a curved spine, bleeding gums, or problems with the heart valves, lungs, or digestion. Symptoms range from mild to extremely severe.

Epidermolysis bullosa (EB) is caused by a gene mutation that makes skin more fragile. The skin of people with EB often blisters or tears at even the slightest bump or sometimes even just from clothing rubbing against it.

More than one type of EB can occur. Depending on the type, the genetic mutation affects how different proteins in your skin, such as keratin, laminin, or collagen, are made.

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Osteogenesis imperfecta is caused by gene mutations that affect the body’s ability to produce collagen. People with different gene defects that fall under this heading typically have:


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