Apoorva Bharathiraja

This therapy is sometimes called immune checkpoint blockade because the molecule that acts as a brake on immune cells — the checkpoint — is blocked by the drug.

Our researchers have played a leading role in developing checkpoint inhibitors and demonstrating their safety and effectiveness in cancer patients.

MSK has helped lead several clinical trials showing that checkpoint inhibitors can be effective against melanoma and lung cancer, and these drugs are being tested at MSK against sarcoma, lymphoma, and several other cancers.

One drug called ipilimumab (Yervoy®) blocks a checkpoint protein called CTLA-4. Two additional drugs, pembrolizumab (Keytruda®) and nivolumab (Opdivo®), target another checkpoint protein called PD-1. A third drug, atezolizumab (Tecentriq®), targets one called PD-L1.These drugs all became available within the last few years. The US Food and Drug Administration (FDA) approved ipilimumab in 2011 and pembrolizumab and nivolumab in 2014, all for the treatment of melanoma. In 2015, the FDA also approved nivolumab and pembrolizumab for non-small cell lung cancer, and nivolumab for renal cell carcinoma.

Several additional checkpoint drugs are being studied and investigated in clinical trials at MSK.

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Subject to peer review.

The research results are presented to a broad audience. They explain the importance of research for public health and the findings in the prevention of chronic diseases

If the research results are relevant to preventing or lessening the effects of a chronic disease, we will accept articles from many disciplines.

Some examples of article topics that meet these requirements can be found here.

The CONSORT statement guidelines can be found at www.consort-statement.org/external icon. All randomized controlled trials described in an original research article must be registered with ClinicalTrials.gov.

Tables, figures, and other images should be easy to understand and visually appealing. The tables, figures, and other images must be consistent with the text.

The results of the operations must be correct. Tables, figures and other images must be readable on their own. The use of photographs, illustrations, press clippings, short video or audio files, multimedia elements or other types of information that complement the article and can be transmitted or linked through the web is recommended.

In the abstract, use the following subheadings: introduction, methods, results, and conclusion. In the body of the article, use the following subheadings: introduction, methods, results, and discussion.

Explain the context of the study, the importance of the study question and its precise objective. If there is more than one goal, please mention the main goal and only the secondary goals.

Provide a brief review of the scientific literature to identify knowledge gaps on the subject of the study and show how your study will add substantially to what is already known. Define terms that are specific to your manuscript. The section should be no longer than 300 words.

The methods state the type of study used. The study dates should be indicated. Explain the essential characteristics of the study if it describes an intervention. Please provide any survey questions that were included in the study. Mention the settings of the selected participants as well as important demographic.

The inclusion and exclusion criteria of the study participants should be specified. Study participant recruitment and sampling procedures should be described. Proof that the study has been approved by the appropriate institutional review board is needed for research involving human subjects. The participation rate is in terms of numerator and denominator.

The required sample size calculations were made before the study began. There should be a section on statistical methods. The established significance level is reported by the statistical software. The active voice can be used.

The results must be relevant to the research hypothesis.

The methods section is where the results must be found. The characteristics of the study participants should be presented. The main results of the study should be provided. Please indicate the response rate for surveys.

The report measures the distribution or precision of the data. Information about how study participants can be compared to people who are not in the study. Explain any results or measures that are new to the public health audience.

If the validation measures were part of the study, describe them.

Discuss the research problem and assess the strengths and weaknesses of the study. Positive and negative findings of equal merit should be put together. The results section can be long. Compare and contrast the findings from the study with those from other studies.

Mention the unexpected findings and give their possible explanations. The study's limitations are stated. The public health implications of the study should be addressed in order to avoid speculation and overgeneralization. If relevant, suggest future studies. The conclusion of this section should be supported by the study findings.

The text must not have more than 3000 words and the abstract must not have more than 250 words. There are no more than 30 references.

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Subject to peer review.

The articles focus on the process of community participation in the context of a program. Promoting two-way communication between researchers and community members is one of the ways in which public health professionals involve community members. A community can be defined by a number of factors. The presentation of the results needs to have information. Simple descriptions of events, such as conferences, are not ideal for this type of article.

The sources of funding for the study should be identified.

Tables, figures, and other images should be easy to understand and visually appealing.

The tables, figures, and other images must be consistent with the text. The results of the operations must be correct. Tables, figures, and other images must be readable on their own.

The use of photographs, illustrations, press clippings, short video or audio files, multimedia elements or other types of information that complement the article and can be transmitted or linked through the web is recommended by us.

In the abstract and the text of the manuscript, use the following subheadings: background, community context, methods, results, and interpretation.

Introduce the disease and problem that the intervention or established program is related to. The scientific knowledge of the disease or problem should be described.

The health problem is important. Define terms that are specific to the manuscript. The section should be no longer than 300 words.

The community where the program is taking place is described. The sociodemographic characteristics of the community are listed.

List other aspects of the community that are relevant to the issue. Tell us about the health problem and how it affects the community. The goal should be stated in two statements: the first should state the goal of the intervention or program, and the second should state the community engagement efforts.

The precise results of interest for community participation activities can be pointed out. The objectives and outcomes of community engagement activities are the focus of a community case study.

Then describe in detail the community engagement plan. How were community members identified as potential partners in the health initiative, should be answered by the Methods section.

How was the partner recruitment done? How was the representation of racial, ethnic, or cultural diversity determined?

Community partners were involved in identifying and modifying the intervention. How did you plan to involve partners in the analysis of the information? The results of the intervention or program were communicated to partners.

How was the information given to the public health professionals? What resources were needed to implement the plan? How were the promotional materials distributed? What was the community engagement schedule?

Explain why you chose certain elements of your method. Make sure the plan for evaluating the achievements of community engagement efforts is based on the stated goal and outcomes of interest If the plan to assess achievement is based on quantitative or qualitative information, you should indicate it.

Proof that the study has been approved by the appropriate institutional review board is required for research involving human subjects.

Evaluate the achievements of community participation activities. If the plan outlined in the Methods section was followed through, focus on the extent to which the activities met the stated objectives.

What did the plan accomplish? The effect of the population's participation in the community was discussed. What new members did they join?

What processes or activities helped or hindered the achievements? What achievements were not expected? How effective were the communication activities when it came to community partners?

Give data about the qualitative or quantitative changes.

The purpose and results of community engagement activities are addressed. Explain how you would do things differently next time, and if the activity was worth it. Advice to other communities about establishing a similar program. Speculation or overgeneralization are not good things to do.

The conclusion of this section should be clear and concise.

The text must not have more than 3000 words and the abstract must not have more than 250 words. No more than 20 references are required.

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Subject to peer review.

The articles give systematic evaluations of scientific articles and information sources. The methods used to conduct the review must be described by the authors.

The reviews will also include meta-analyses. Mini-reviews can provide historical insights or summaries of developments in rapidly developing areas.

Tables, figures, and other images should be easy to understand and look good. The tables, figures, and other images must be consistent with the text. The results of the operations must be correct.

Tables, figures, and other images must be readable on their own. The use of photographs, illustrations, press clippings, short video or audio files, multimedia elements or other types of information that complement the article and can be transmitted or linked through the web is recommended by us.

In the abstract, use the following subheadings: introduction, methods, results, and conclusion. In the body of the article, use the following subheadings: introduction, methods, results, and discussion.

Explain the importance of the review approach.

The precise primary objective should be indicated. The section should not be more than 300 words.

The Methods section should include information sources, study selection, and data extract.

There are information sources.

The search strategy should be described. Accurately summarize the sources of information. The exact years should be indicated. You can use the most up-to-date information for your searches.

It is recommended that searches be made no later than several months in advance of the submission of the manuscript. Consider all the possible sources of information. Provide the exact search terms that you used to find the articles. Mention the limitations in the searches.

The study selection is done. The studies that are the subject of the detailed review have inclusion and exclusion criteria. Specific information about the disease, population, intervention, methodological design, and outcome under study can be highlighted.

The method used to identify and apply the exclusion criteria is indicated. Determine the proportion of articles that met the selection criteria.

Data is being retrieved. The parameters used to extract the information are described. The quality and validity of the information are assessed using parameters.

Information on how the parameters were applied is needed. A description of how the information will be analyzed is required to end this section.

The main results are stated in the first paragraph. All outcomes should be relevant to the question. The methods section is where the results must be found. The distribution or precision of the data can be reported for numerical results.

Discuss strengths and weaknesses of the study. Positive and negative findings should be put in the same sentence. The results section can be long.

Compare and contrast the findings from the study with those from other studies. List and explain the results. The limitations of the study and the generalizability of the results should be addressed.

If relevant, state the implications for public health and propose possible future studies. The conclusion of the section should be supported by the findings.

The main topic of the review should be the focus of the interpretation of the information.

The text must not have more than 3,500 words, and the abstract must not have more than 300 words.

There is no limit.

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Subject to peer review.

The original material in these articles is similar to the original research and community case studies.

There are recommendations from the National Panel of Experts on Community Health Promotion, a theoretical interpretation of the population attributable fraction, and a practical evaluation of cessation interventions in the articles.

The PCD's mission is to serve as an interface between applied intervention research and public health practices in the prevention of chronic diseases, and the article must clearly focus on a particular disease or aspect of the reduction or prevention of chronic diseases. The article needs to be timely and offer a significant contribution to what is already known about public health practice. Define technical terms and justify your reasoning.

The methods presented are either statistical or analytical The samples must be large enough to make a difference.

Explain the results to the audience. The conclusions must be supported by evidence.

The implications for public health and the direction of future research are addressed. Funding sources in the Acknowledgments can be identified. Current and relevant citations are what they must be.

Tables, figures, and other images should be easy to understand and look good. The tables, figures, and other images must be consistent with the text.

The results of the operations must be correct. Tables, figures, and other images must be readable on their own. The use of photographs, illustrations, press clippings, short video or audio files, multimedia elements or other types of information that complement the article and can be transmitted or linked through the web is recommended by us.

The text must not have more than 2500 words and the abstract must not have more than 150 words. No more than 25 were references.

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Peer review is subject to review.

The results of research are presented to a broad group of public health professionals. They explain the importance of research for public health and the relevance of the findings for the prevention of chronic diseases.

If the research results are relevant to preventing or lessening the effects of a chronic disease, we will accept articles from many disciplines.

There should be no more than two figures or two tables. Tables and figures should be easy to understand and visually appealing. The information in the tables must be consistent with the text. The results of the operations must be correct.

The tables and figures must be read on their own. The use of photographs, illustrations, press clippings, short video or audio files, multimedia elements or other types of information that complement the article and can be transmitted or linked through the web is recommended by us.

The abstract should not have more than four sentences, each of which should be related to the topic of the article.

The section should be 100 words. The main purpose of the research and the main hypothesis to be tested should be described.

Explain the importance of the study question. Defines of context-specific terms

The section should not be longer than 300 words. The type of study design used is listed. The dates are specified.

If the study describes the intervention's essential characteristics, that's it. The setting from which the participants were selected is described. The inclusion and exclusion criteria of the participants should be specified.

Proof that the study has been approved by the appropriate institutional review board is required for research involving human subjects. Please indicate the participation rate in terms of the numerator and denominator. The controls were used.

The required sample size calculations were made before the study began. Information about the statistical methods can be written down.

The section should not be more than 300 words.

Report only on the results that are relevant. The results have to be relevant to the research hypothesis. The methods section is where the results must be found.

Important characteristics of study participants can be presented. Please indicate the response rate for surveys. The distribution or precision of the data is reported. Information about how study participants can be compared to people who aren't in the study.

If the study includes validation measurement, describe them.

The section should not be more than 300 words.

State the strengths and weaknesses of the study in the research question. Positive and negative findings of the same scientific merit should be put in equal emphasis. The results section can be lengthy. Mention the unexpected findings and give possible explanations.

The results of the study may be limited. If relevant, suggest possible future studies. The conclusion of this section should be supported by the study findings.

The text must not have more than 1,000 words and the abstract must not have more than 100 words.

There are no more than 12 references.

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Peer review is subject to review.

However, most are unaware that there are two distinct symbols commonly used which have very different origins The Staff of Asklepios is a rough-hewn branch

Griffith University has five campuses between Brisbane and the Gold Coast in south-east Queensland, as well as a digital campus Our physical campuses are

Bastianich has co-authored two award-winning books on Italian wine, and his memoir, Restaurant Man, became a New York Times Best Seller within a week of its release in May 2012. He claims to have invented the Everything bagel in 1979, although this feat is also claimed by other people.