Hayley Grohl

When your loan amount is more than your vehicle is worth, gap insurance coverage pays the difference. For example, if you owe $25,000 on your loan and your car is only worth $20,000, your gap coverage covers the $5,000 gap, minus your deductible.

Study questions.

1 Taxol was originally obtained from the bark of the yew tree, and more potent derivatives were obtained with semisynthetic approaches. (V)

That's how it ended.

Taxol from yew bark would have meant the destruction of yew forests.

There are 2.

Taxol and taxotere block the breakdown of the tubulin from the microtubules. The letter F is used to indicate the situation.

The first part of the question is correct. The second part is not because by blocking the disassembly of the turbulin from the cytoskeleton, microtubules accumulate.

3.

The vinca alkaloids have the same mechanism of action. (F)

The cell cycle is disrupted when Vinca alkaloids bind to beta-tubulin. They block its polymerization with alpha-tubulin to form microtubules by binding to it.

There are 4. It is difficult to administer paclitaxel because of its poor solubility.

A nanoparticle of albumin, called nab-paclitaxel, was created to facilitate its solubility and iv injection. (V)

It is true. The vehicle used to administer paclitaxel was made out of 50% ethanol and 50% polyethoxylated castor oil, and it was surely responsible for a high prevalence of hypersensitivity reactions. Nab-paclitaxel is water-soluble and can be administered safely without the need for prophylactic treatment.