Sekhar Thiagaraj

Here I'll show you how to take results from DESeq and quickly assess for enrichment of pathways using the fgsea package for fast preranked

Hyaluronan is found ubiquitously throughout the mammalian body.  It is either directly or indirectly involved in every physiological function of the body.  It is found in dense concentrations in cartilage, synovial fluid, skin, vertebral discs, bones, urinary tract, cardiac valves, eyes, and various other soft tissues.  Hyaluronan is most abundant during embryogenesis and declines in overall quantity and quality throughout life (McDonald, 2002).

Canonically, hyaluronan is recognized for its role in the maintenance of joint health.  Hyaluronan is naturally synthesized locally by synoviocytes within the joint and once produced, it binds to collagen and elastin to form articular cartilage.  It is the presence of hyaluronan that makes cartilage strong enough to handle compressive forces within the joint (Seog, 2002).  Hyaluronan is also found in unbound form in the synovial fluid, where it provides the major source of lubrication that allows for smooth fluid movements in joints (Sabaratnam, 2005).

Hyaluronan within the synovial capsule is critical for smooth joint movement: the articular cartilage encapsulates the ends of the bones forming a smooth while synovial fluid forms a film of lubrication over the articular cartilage during movement.  Combined, these structures protect the bones from frictional grinding (Walker, 1968).

Within bone itself, the presence of hyaluronan is primarily linked to its roles in bone modeling and remodeling processes.  Hyaluronan has been shown to regulate bone remodeling by stimulating osteoblasts and osteocytes as well as inhibiting osteoclasts (Bastow, 2008; Prince, 2004).  Intriguingly, hyaluronan taken orally has been shown to reduce urinary markers of bone resorption and ovariectomy-induced bone loss (Gerdin, 1997), indicating that hyaluronan may suppress bone resorption.

One of the primary functions of hyaluronan is maintaining tissue hydration.  Interestingly, hyaluronan is so hydrophilic it can absorb, retain, and deliver over one-thousand times its weight in water (Wand, 2007).  The ubiquitous nature of the molecule ensures that hydrophilic delivery takes place throughout all tissue.

Hyaluronan is found most prevalently in the skin; approximately half of total body hyaluronan is located within the dermal and epidermal layers.  Primary functions of hyaluronan in the skin include moisturization and hydration (Meyer, 1941).  Skin turgor is the result of the ability of hyaluronan to absorb, retain, and deliver water (Wang, 2007).  With age, there is a distinct decrease in the percent composition of hyaluronan in epidermal tissue likely correlating with the increase in wrinkles and aged skin (Juhlin, 1997).  Experiments have demonstrated that 77% of naturally occurring hyaluronan in the skin is lost by age 70 in humans (Weist, 2008).

Hyaluronan makes up a large part of the vitreous humor (the space-filling jelly between the lens and the retina) and is also found in the lacrimal gland, cornea, conjunctiva, and in tears (Gong, 1994).  Ocular functions of hyaluronan include homeostasis, moisturization, and lubrication.

Hyaluronan has established itself as a protectant by its ability to confer defense to gut mucosal tissue.  A recent study aimed to evaluate the effects of hyaluronan on gastric mucosa (Al-Bayaty 2011).  Laboratory findings revealed that a high-molecular-weight hyaluronan-containing gel significantly protected the gastric mucosa.

Oral hyaluronan has been shown to be absorbed and effective (Ma, 2008).  Recent clinical studies are consistent with these laboratory findings (Lukens, 2005; Kiburz, 2006).  Studies with (99m)-technetium-labeled, high-molecular-weight hyaluronan administered orally show distribution to the joints in as little as four hours (Balough, 2008).

To be compared to the CSG family of products, any oral hyaluronan supplement must be bioavailable, absorbed, and effective.  Hyaluronan must be completely hydrated in order to be bioavailable and absorbed.  Once absorbed it must have the appropriate molecular characteristics to be effective.

This seems to be a very popular subject recently. Let's hear everyone's experence on the RMA process they had with different motherboard

Top 10 Cookware Brands In India for Online Shopping. Prestige; Pigeon; Hawkins; Wonderchef; Vinod Cookware; Sumeet; Bergner; Bajaj; BMS

As everybody has already said, it's historical reasons in that Wales didn't set up a league until years after Cardiff, Swansea & Wrexham were playing within the

1 Mountain Sun. Where: 1535 Pearl St., Boulder; 3 · 2 The Sink. Where: 1165 13th St., Boulder; 3 · 3 Dark Horse. Where: 2922

Device Class · Class 1 - Devices subject to General Controls, · Class 2 - Devices subject to General Controls and Special Controls, · Class 3 -

What is SOSTAC® planning? SOSTAC® has six steps; it stands for Situation, Objectives and Strategy, Tactics, Action and Control. Here I relate it to the chapters of my Digital Marketing: Strategy and Implementation book.

Seeing hundreds, if not thousands of campers each year, the Alabama Hills Recreation Area, run by the BLM, is one of the most popular spots for

Source: thedyrt.com

1. Adding a continuous field on the Rows shelf adds an additional axis to the rows of the table.
2. Adding a continuous field on the Columns shelf adds an additional axis to the columns of the table.

EASY UNDERSTANDING OF GEARING ( TOL / TNW ) FOR BUSINESS OWNERS AND ENTREPRENEURS ; B = Long Term Liabilities ; C = Share + Capital + Reserve ; A + B is the amount

For the details how to install Qbs, see the Installing page. To build applications from the command line, enter the following commands: cd examples/collidingmice

In many cases, the minimum education needed to become a loss prevention agent is a high school diploma" · Uploaded by The Study.com Video Team

1. Open the Settings app.
2. Go to Ease of access -> Keyboard.
3. On the right, scroll down to the Print Screen key section.
4. Turn on the option Use the Print Screen key to launch screen snipping.