Ratnamala Rajnikanth

Both women and men can develop IBC. Compared to other forms of breast cancer, IBC tends to strike younger women and is more common in Black women than White women. Men who are diagnosed with IBC are older on average than female patients. IBC is often mistaken for other conditions. It's important to talk with a healthcare provider if you are experiencing symptoms.

This article will discuss the symptoms, diagnosis, and treatment of inflammatory breast cancer.

IBC is a fast-growing cancer that can block lymph and blood vessels in the breast. As a result, signs and symptoms develop quickly, sometimes over weeks or months. IBC may not contain a solid tumor that you can feel, and symptoms can be similar to those of other conditions.

It is essential to watch for physical changes and describe them to your healthcare provider.

Common symptoms of IBC include:

Researchers aren't sure what causes IBC specifically, but some risk factors have been identified, including:

IBC can be challenging to identify, but there is a set of criteria to help healthcare providers reach a diagnosis, such as:

Your healthcare provider will perform a clinical breast exam, including a visual check of your breast. This involves looking for changes in skin color that may be caused by cancer cells blocking the lymph nodes and vessels in your breast skin. If your breast is swollen, it may be caused by fluid buildup, a condition called edema.

If your breast skin is ridged, pitted, bumpy, or resembles an orange peel, that will also be noted.Your healthcare provider will also check the lymph nodes in your armpits.

After taking a careful medical history and doing a physical exam, your healthcare provider will likely order imaging studies or perform a breast biopsy to understand your symptoms further. These studies help diagnose IBC and help rule out conditions, such as mastitis, that can cause similar symptoms.

These tests include:

If a mass is noted, a breast biopsy may be performed. If a mass is not present, a skin biopsy will be done on the abnormal area of the affected breast.

IBC does not always present with a lump like other cancers. Instead, it grows in sheets (sometimes called "nests") and can spread through the body primarily via the lymphatic system.

IBC is classified either as stage 3 or stage 4, depending on how far it has spread in the body. Stage 3 cancers have spread to at least one lymph node but not to other body regions. Stage 4 cancer is similar to stage 3B, but the cancer has spread to distant body areas.

Inflammatory breast cancer is aggressive. Therefore, it is usually treated with a combination of therapies (sometimes called a "multimodal approach") to reduce the risk of recurrence.

Neoadjuvant chemotherapy refers to chemotherapy that is administered prior to surgery. A combination of drugs is usually given in cycles for four to six months, depending on how quickly the cancer is growing. In some cases, patients may receive additional chemotherapy after surgery (called adjuvant chemotherapy).

The most common surgery is modified radical mastectomy (removing the entire breast), which is similar to a mastectomy for other types of breast cancer. With IBC, however, the lining of the chest muscles is also removed. Sometimes, one of the chest muscles (pectoral minor) may be removed. In addition, most lymph nodes are also excised.

If women desire reconstructive surgery (plastic surgery to restore the appearance of the breast), it is usually delayed until at least six months after completion of radiation therapy.

Radiation therapy is usually performed after a mastectomy to treat the chest wall and remaining lymph nodes.

Many inflammatory breast cancers are HER2 positive (a protein that makes cancer grow), so treatment with HER2-targeted therapies can be effective in controlling the tumor. These drugs are usually given along with the other treatments after a diagnosis of IBC. If the cancer is sensitive to estrogen, hormone therapy may also be an option.

There are a number of clinical trials in progress for inflammatory breast cancer that are evaluating the combination of the treatments above as well as newer treatments, such as immunotherapy (treatment that uses your body's immune system to help fight cancer).

IBC has a higher risk of recurrence than some other forms of breast cancer. However, if recurrence does occur, treatment is available and may include HER2-targeted therapies, chemotherapy, or hormonal therapy. In addition, other medicines may be available in clinical trials.

Recurrence is possible at any time, whether months after treatment or years down the road, including:

Healthcare providers cannot predict which tumors will result in a recurrence with certainty.

The highest risk of recurrence occurs in the first few years following treatment. A person's risk of recurrence is reduced after being cancer free for five years.  IBC tends to come back earlier because it's more aggressive, progressing more quickly than other types of breast cancer.

After IBC treatment, healthcare providers monitor patients periodically to check for recurrence. Physical exams are done at follow-up visits every three to six months after diagnosis for the first three years, then space out to one to two times yearly. These checkups include annual mammograms.

Because the potential for recurrence with IBC is high, healthcare providers recommend performing monthly breast self-exams and paying close attention to symptoms of recurrence.

Inflammatory breast cancer is aggressive and affects both men and women. Symptoms include skin changes such as redness, rash, or dimpling. Once a biopsy and imaging are complete, IBC can be staged. Treatment for this type of breast cancer can include chemotherapy, hormonal therapy, or targeted therapy. You may also need surgery and radiation to treat IBC. Many clinical trials are looking into better treatment options for IBC.

Although getting a cancer diagnosis is difficult and life altering, it's important to remember that each person and every cancer is different. While treatment for IBC can be challenging there are long-term survivors of this disease. In addition, newer treatments often have fewer side effects than traditional chemotherapy drugs.

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