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Cyclobenzaprine (sold under the brand name Flexeril, among others) is a muscle relaxer used for muscle spasms from musculoskeletal conditions of sudden onset. It is not useful in cerebral palsy. It is taken by mouth. Use is not recommended for more than a few weeks.

Common side effects include headache, feeling tired, dizziness, and dry mouth. Serious side effects may include an irregular heartbeat. There is no evidence of harm in pregnancy, but it has not been well studied in this population. It must not be used with an MAO inhibitor. How it works is unclear.

Cyclobenzaprine was approved for medical use in the United States in 1977. It is available by prescription as a generic medication. In 2020, it was the 39th most commonly prescribed medication in the United States, with more than 16 million prescriptions. It was not available in the United Kingdom as of 2012.

Cyclobenzaprine is used, in conjunction with physical therapy, to treat muscle spasms that occur because of acute musculoskeletal conditions. After sustaining an injury, muscle spasms occur to stabilize the affected body part, which may increase pain to prevent further damage. Cyclobenzaprine is used to treat such muscle spasms associated with acute, painful musculoskeletal conditions. It decreases pain in the first two weeks, peaking in the first few days, but has no proven benefit after two weeks. Since no benefit is proven beyond that, therapy should not be continued long-term. It is the best-studied muscle relaxer. It is not useful for spasticity due to neurologic conditions such as cerebral palsy.

A 2004 review found benefit for fibromyalgia symptoms, with a reported number needed to treat of 4.8 (meaning that 1 person out of every 4.8 benefits from treatment) for pain reduction, but no change in fatigue or tender points. A 2009 Cochrane review found insufficient evidence to justify its use in myofascial pain syndrome. It may also be used along with other treatments for tetanus.

Cyclobenzaprine results in increased rates of drowsiness (38%), dry mouth (24%), and dizziness (10%). Drowsiness and dry mouth appear to intensify with increasing dose. The sedative effects of cyclobenzaprine are likely due to its antagonistic effect on histamine, serotonin, and muscarinic receptors.

Agitation is a common side effect observed, especially in the elderly. Some experts believe that cyclobenzaprine should be avoided in elderly patients because it can cause confusion, delirium, and cognitive impairment. In general, the National Committee for Quality Assurance recommends avoiding the use of cyclobenzaprine in the elderly because of the potential for more severe side effects.

Dysphagia, a life-threatening side-effect, may rarely occur. Treatment protocols and support should follow the same as for any structurally related tricyclic, such as tricyclic antidepressants.

The most common effects of overdose are drowsiness and tachycardia. Rare but potentially critical complications are cardiac arrest, abnormal heart rhythms, severe low blood pressure, seizures, and neuroleptic malignant syndrome. Life-threatening overdose is rare, however, as the median lethal dose is about 338 milligrams/kilogram in mice and 425 mg/kg in rats. The potential harm is increased when central nervous system depressants and antidepressants are also used; deliberate overdose often includes other drugs.

Cyclobenzaprine has major contraindications with monoamine oxidase inhibitors (MAOIs). At least one study also found increased risk of serotonin syndrome when cyclobenzaprine was taken with the serotonergic drugs duloxetine or phenelzine.

These substances may interact with cyclobenzaprine:

Cyclobenzaprine may affect the medications used in surgical sedation and some surgeons request that patients temporarily discontinue its use prior to surgery.

Cyclobenzaprine is a centrally acting muscle relaxant. Cyclobenzaprine is a 5-HT2 receptor antagonist; it relieves muscle spasm through action on the central nervous system at the brain stem, rather than targeting the peripheral nervous system or muscles themselves.

Cyclobenzaprine has an oral bioavailability of about 55% and approximately 93% is bound to proteins in plasma. The half-life of the drug is 18 hours and it has a plasma clearance of 0.7 litres per minute.

Cyclobenzaprine has been found to be not inferior to tizanidine, orphenadrine, and carisoprodol in the treatment of acute lower back pain, although none have been proven to be effective for long-term use (beyond two weeks of treatment). No differences in pain or spasm scores were noted among these agents, nor when compared to benzodiazepines. However, nonbenzodiazepine (including cyclobenzaprine) treatment was found to have a lower risk of medication abuse and continuation of use against medical advice. Side effects such as sedation and ataxia are also less pronounced with nonbenzodiazepine antispasmodics.

In a study on the treatment of musculoskeletal pain treatment with cyclobenzaprine alone or in combination with ibuprofen, no significant differences in pain scores were noted among the three treatment groups. Peak benefit was found to occur on day seven of the treatment for all groups.

By mouth, cyclobenzaprine is marketed as Apo-Cyclobenzaprin, Fexmid, Flexeril and Novo-Cycloprine. It is available in generic form. A once-a-day, extended-release formulation, Amrix, is available. Cyclobenzaprine is also used by compounding pharmacies in topical creams.

Just like the hair on your head, your beard hair also requires maintenance and care. This is where beard oils come in handy. These nifty grooming products help reduce itching and dandruff, leaving the hair smooth, silky and neatly kept. By moisturising and conditioning the hairs, it also makes it even easier to style.

Applying beard oil is a rather simple process. That said, there are some things to keep in mind especially if you’re a beginner to beard oil or grooming in general. In this Academy article, we’ll teach you how to correctly apply beard oil in 4 easy steps.

Your beard should be clean, towel-dried but still slightly damp from water or after a shower (but not too wet or the beard oil won’t stick). Begin by applying a few drops into the palm of your hand. We recommend around 3-6 drops, depending on the length of your beard. If you're a beginner, less is more and as you familiarise yourself with the process, you’ll eventually get a good idea of how much you need.

Rub your hands together to spread the product evenly, then run them through the beard. First, you want to press the beard oil into the skin to ensure it moisturises the roots of your beard and the skin surrounding it.

Once you’ve applied to the roots and skin, start applying directly to the beard. Start with sides of the beard and work your way down by moving your hands in a downward swipe motion. Brush your hands down the front in the same downward swipe motion. Then brush your hands upwards from the neck to get the bottom of the beard too.

If you have a moustache, use your pointer fingers and swipe them down the front a few times. To finish, use a comb to continue evenly distributing the product across the beard until soft and conditioned.

Beard oils have a slew of benefits including (but not limited to):

The best time to apply beard oil is straight after a shower. This is because your beard is completely clean and your pores have opened up from the steam, making for easier absorption of the product.

We actually wrote an article about their differences which you can read. Simply put, the difference is mainly in texture–beard oils are lighter whereas beard balms are heavier. Beard balms are useful for styling the beard, while beard oils are best suited for men with short to medium-length beards.

You certainly can. Beard oils have many moisturising ingredients that can soften your skin and prevent dryness even if you have little, or no, beard hair.

It’s honestly up to you, but we generally advise applying it every time after every shower and whenever it feels itchy and uncomfortable.

While there is no "best" beard oil, many beard oil users will have their favourites. The various scents available are one reason, but so too are the types and quality of the included ingredients. Keep an eye out for beard oils containing argan, jojoba or almond oils.

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Bowlegs can sometimes be a sign of an underlying disease, such as Blount's disease or rickets, and may lead to arthritis in the knees and hips Treatment

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