Muhammad Artur

Beta-hydroxy-beta-methyl butyrate, or HMB for short, is made in our body from the amino acid leucine. Leucine has been known as a powerful nutritional supplement for increasing strength, muscle, and decreasing body fat.1 Leucine has also used for years to prevent muscle fatigue and soreness, which previously made researchers believe that it was also responsible for slowing breakdown of muscle proteins, or proteolysis.1 However, it’s actually HMB, which comes from leucine, that slows this protein breakdown. The combination of benefits that leucine and HMB provide can make a dramatic difference in your workouts and body composition over time.

Beta-hydroxy-beta-methyl butyrate, or HMB, is a chemical produced by the body when breaking down the amino acid, leucine. It is often used to slow down muscle protein breakdown.

In short, HMB works in two ways — increasing protein synthesis while decreasing protein breakdown.1 This combined anti-catabolic (anti-muscle protein breakdown) and anabolic (muscle protein building) impact means you build lean mass more efficiently – so, that’s greater gains in muscle and strength.2

While you build muscle and increase your strength, you’ll have greater power and reduced muscle breakdown after exercise with consistent HMB supplementation. As your lean body mass increases from building muscle, you’ll increase your metabolism and will be able to level up your workouts. Studies have shown varying impacts of HMB supplementation based on an individual’s fitness level and type of exercise, so let’s break them down one at a time.

One study compared strength performance results of sedentary, overweight women before and after six weeks of supplementing with HMB. Although there was weight loss and fat loss over the course of the study in the group who took HMB, the significant impact was the improvement in their strength performance after 6 weeks (without following a weight training routine).3 This study proved that HMB can increase muscle strength without exercise, even in overweight, sedentary individuals.3

Those who are new to intense training like weightlifting seem to benefit the most from HMB. Since a new high-intensity exercise routine increases the likelihood of muscle damage that needs repairing, HMB can have a hugely positive effect. It is in this population that several studies saw increases in lean body mass and strength, but this is likely to also be due to the combination of a new training routine with supplementation.1

Those who are trying to up their strength and work their muscles to hypertrophy (muscle growth) are likely performing intense activities that leads to muscle damage. This type of intense training leads to muscle soreness and longer recovery periods. Experienced athletes following this type of training can use HMB to reduce soreness, damage, and shorten recovery by boosting muscle synthesis and slowing breakdown. HMB enables these types of athletes to train more often and see benefits more quickly.1

A study of a small group of elite male rowers compared the impact of HMB on endurance cardiovascular training. Twelve weeks of HMB supplementation increased the athletes’ VO2 max (aerobic endurance) and decreased their body fat.4 The study also indicated that the HMB supplementation might have a positive impact on peak anaerobic power as well.4

The main benefit of HMB it its ability to create a net positive balance of muscle turnover — that’s more muscle building than breakdown.1 For this reason, taking HMB while also cutting calories for weight loss, can help preserve lean body mass while targeting fat mass. This can be useful for people who are trying to lose weight without losing muscle.

Another promising study focused on the change of HMB levels as we age, showing that there’s a general decline in HMB as we age (correlated with losing muscle).5 The study also discovered that individuals with higher levels of HMB had greater muscle mass and greater strength than those with lower levels.5

Overall, the beneficial effects of HMB seem to be tied with intensity of the training and level of the athlete who is taking it. The groups who seem to have the greatest benefits from taking HMB are trained athletes who perform intense, challenging workouts that would otherwise be more damaging to the muscles.6 While there’s evidence of increase in strength in groups who are brand new to resistance training, it may be less effective for the occasional exerciser or someone who doesn’t perform very challenging workouts.7

HMB has consistently been shown to benefit those who are new to weightlifting and those who are dramatically increasing the intensity of their workouts by preventing muscle damage.1 There’s less effect in highly trained individuals who aren’t performing exercises that challenge their bodies.

HMB is produced by our bodies from the amino acid leucine. When present in high enough concentrations, it works by speeding the recovery of muscle after prolonged or intense exercise.1 Many studies also show varying degrees of reduced muscle soreness and faster recovery when taking HMB consistently.

Because HMB is a product of leucine, to increase your dietary intake you should focus on foods that are high in leucine. High levels of leucine are typically found in high-protein animal-and plant-based foods.8 Examples include:

The greater the amount of leucine in your diet, the more HMB will become available, but only about 5% of leucine is converted to HMB. For this reason, an HMB supplement is the most efficient way to get more in your diet.

HMB supplements can be available as powdered or capsule forms. Sometimes the HMB is combined with calcium (HMB-Ca) and other times it’s considered a “free acid”, or HMB-FA.1 Most products on the market as supplements are the HMB-Ca form, but some research shows that the free acid (FA) form works more quickly, and may become a more popular option in the future.1 Sometimes HMB is sold in combination with creatine due to its similar additive effects.

Several different research studies support the theory that the greatest benefit from supplementing with HMB happens when you consistently supplement with HMB for two weeks before changing or intensifying your training.1

The recommended dosage is 3 grams of HMB-Ca at least one hour before intense exercise, but ideally “loading” with 1g, 3 times a day for two weeks before a change in training routine and intensity.1 The HMB-FA form acts more quickly, so this can be taken in a 1-2g dose between 30 and 60 minutes prior to exercise.1

When taken with carbohydrates or as part of a meal, HMB might take longer to become available for maximum benefit. For this reason, if carbs are taken at the same time, consume your HMB about 2 hours before your training session.1

HMB is an effective supplement for those who want to speed up their recovery from high-intensity exercise — both weight training and endurance cardio. It helps to boost and preserve muscle mass and strength, and can be useful for weight loss.1,5

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