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CLogP is seen in small molecule design puzzles. It's a measure of how hydrophilic or hydrophobic a ligand is. The ligand's cLogP can be displayed, and may figure in an objective that awards or subtracts points.

CLogP is a "partition coefficient", the ratio between the concentration of a substance in two different solvents. The "c" in the name represents "calculated", the "log" means "logarithm", and "P" refers to "partition". See partition coefficient on wikipedia for more detail.

The higher the cLogP, the more hydrophobic a substance is. Foldit puzzles typically include an objective that deducts points if cLogP is higher than 2.75.

CLogP is a critical measure for drug design. Successful drugs tend to have lower cLogP, meaning they are more hydrophilic.

CLogP is the ratio of two measurements using the same unit, so it's a unitless or dimensionless value, lacking its own unit of measure.

It's possible to measure an actual log(P) value using two solvents, n-octanol and water. In effect, oil and water. A substance is dissolved in a mixture of the two solvents, which then separate. ("Oil and water don't mix.") The concentration of the substance in each solvent is then measured. The concentration in n-octanol becomes the numerator of the ratio, and the concentration in water, the demoninator.

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