Yolandi McIlwaine

Bupropion is an antidepressant medication used to help treat the symptoms of depression. Its most common side effects are similar to those of many other medications prescribed to treat depression. As with other antidepressants, most side effects that are associated with bupropion occur in the first few weeks of treatment and go away over time.

Common side effects of bupropion include:

Of these, the most common side effects reported in clinical trials of bupropion were constipation, dizziness, dry mouth, headaches/migraines, nausea/vomiting, excessive sweating, agitation and tremor, which were all reported by more than 20 percent of users.

Agitation was the most common side effect reported in clinical trials of Wellbutrin, a medication containing bupropion prescribed to treat major depressive disorder (MDD) and seasonal affective disorder. According to data from the FDA, 31.9 percent of people reported agitation while using bupropion.

Other side effects associated with agitation include insomnia, which affected about 18 percent of bupropion users in clinical trials.

If you feel agitated after using bupropion and don’t notice this side effect improving in the first few weeks of treatment, talk to your healthcare provider. They may adjust your bupropion dosage or recommend other changes to manage this side effect.

Try to exercise regularly. Other techniques that may help include deep-breathing exercises and yoga. If you continue to feel agitated while using bupropion, you may also want to talk to your healthcare provider about using medication to help you relax or switching to a different antidepressant.

If you find it difficult to sleep after taking bupropion, avoid taking your medication close to your bedtime. Using bupropion earlier in the day will mean that a lower dose of the medication will be in your bloodstream at bedtime, which may make it easier for you to fall asleep.

And vice versa, if you find yourself saying, “Boy, Wellbutrin makes me tired” it may be worth talking to your healthcare provider about taking it at night, closer to bedtime.

Bupropion and other antidepressants may cause xerostomia, or dry mouth. This side effect was reported by 27.6 percent of people who were prescribed bupropion in clinical trials, making it the second-most common side effect after agitation.

Dry mouth is a common side effect of many antidepressants, not only bupropion. It may be due to changes in your salivary glands caused by the medication. This side effect is generally more common with older antidepressants, such as tricyclic antidepressants (TCAs).

If you get dry mouth while using bupropion that doesn’t improve over the course of a few weeks, it’s best to talk to your healthcare provider. You can also try chewing sugarless or CPP-ACP gum to stimulate saliva production, which may help to loosen mucus and keep your mouth moist.

Headaches and migraines are a fairly common side effect of bupropion, affecting 25.7 percent of people in clinical trials (versus 22.2 percent of people given a non-therapeutic placebo).

Like dry mouth, headaches are a common side effect of antidepressants. Interestingly, a 2012 study found that headaches were less common in bupropion users than in people prescribed SSRIs and other antidepressants.

As with other side effects of bupropion, your headaches may become less severe or go away completely as your body gets used to the medication. If you get persistent headaches, it’s best to talk to your healthcare provider.

Nausea and vomiting are common side effects of bupropion, reported by 22.9 percent of people in clinical trials.

As with many other side effects of bupropion, nausea and vomiting are common side effects of many antidepressants. Nausea caused by bupropion may get better or disappear completely over time as you become more used to the effects of the medication.

If you often feel nauseous after using bupropion, try to take your medication with food, eat small and frequent meals and make sure that you stay hydrated. You can also try an over-the-counter antacid such as Pepto-Bismol® to provide temporary relief.

If you have persistent nausea or vomiting that doesn’t get better over time or with treatment, it’s best to talk to your healthcare provider.

According to clinical trial data, 26 percent of people who use bupropion experience constipation as a side effect.

Like many other side effects of bupropion, constipation is a common side effect of medications used to treat major depression or the symptoms of depression. It’s particularly common with older antidepressants such as tricyclic antidepressants, as these medications can affect digestive function.

If you feel constipated after using bupropion or are experiencing Wellbutrin stomach pain, try increasing your intake of fiber-rich foods or use an over-the-counter fiber supplement. Other techniques that may help include drinking plenty of water and exercising regularly.

If you have severe, persistent or painful constipation after you start using bupropion, talk to your healthcare provider. They may recommend a non-prescription stool softener such as docusate sodium to ease your symptoms and make going to the toilet easier.

Dizziness is a relatively common side effect of bupropion, reported by 22.3 percent of people in clinical trials.

In addition to bupropion, several other antidepressants can cause dizziness. You may feel dizzy when you first start taking bupropion, or notice occasional dizziness when you stand up from a seated position or make other sudden movements.

To avoid dizziness, try avoiding caffeine, tobacco and alcohol while you use bupropion or other antidepressants. It can also help to avoid driving or operating machinery and practice standing up slowly when you need to get up. If necessary, you can use other items for support.

If you feel dizzy during the daytime, you can also talk to your healthcare provider about taking Wellbutrin at night, which may help to reduce the severity of this side effect.

Another relatively common side effect of bupropion users, 22.3 percent of people in clinical trials experienced excessive sweating — a significantly larger percentage than those given a non-therapeutic placebo.

Sweating is a common side effect of antidepressants. It’s referred to as antidepressant-induced excessive sweating, or ADIES, and is estimated to affect between four and 22 percent of people who use antidepressants overall.

Excessive sweating from antidepressants usually affects the scalp, face, neck and chest areas, with symptoms often developing in bursts.

If you notice yourself sweating excessively or uncomfortably after you start using bupropion, it’s best to talk to your healthcare provider. They may prescribe medication to treat the sweating or switch you to new antidepressant or different dosage of bupropion.

Tremors — involuntary muscle contractions that usually affect your hands, limbs, head, face or eyes — is a common side effect of bupropion, affecting 21.1 percent of people in clinical trials.

Like other bupropion side effects, tremor is a common side effect of antidepressants, including selective serotonin reuptake inhibitors (SSRIs) and tricyclic antidepressants. It’s referred to as drug or medication-induced tremor (MIT) and can also occur with other medications.

If you get tremors after you start using bupropion, talk to your healthcare provider. Medication-induced tremors as usually treated by ending treatment with the medication that causes the tremors. They may also recommend adjusting your dosage or using a different type of antidepressant.

Antidepressants are often associated with sexual side effects, such as decreased sexual desire, erection problems, reduced sexual excitement and difficulty ejaculating.

These adverse effects are a particularly common occurrence in people who use selective serotonin reuptake inhibitors (SSRIs) and serotonin norepinephrine reuptake inhibitors (SNRIs).

In a 2000 article, researchers found that 30 to 40 percent of patients prescribed antidepressants developed some degree of sexual dysfunction. Other research has found that between 25 and 73 percent of SSRI and SNRI users reported sexual side effects.

Interestingly, although some bupropion users report experiencing a decrease in sexual function, research tends to show that bupropion is less likely to cause sexual side effects than other antidepressants, and may even help to reverse antidepressant-related sexual issues.

In a 2008 review, researchers noted there’s robust evidence that bupropion tends to cause less sexual dysfunction than SSRIs.

A separate study from 2004 also found that a sustained-release version of bupropion increased sexual desire and frequency of sexual activity in people with SSRI-induced sexual dysfunction.

In other words, bupropion may not cause the same sexual side effects as other antidepressants, or at least not cause them as often or severely. Still, if you notice any changes in your interest in sex or sexual performance after starting bupropion, it’s best to talk to your healthcare provider.

Antidepressants are commonly associated with weight gain. This association is so strong that many people who are prescribed antidepressants stop using them either due to weight gain or concerns about weight gain during treatment.

Although there’s some evidence that you may gain weight after you start using antidepressants, the link isn’t as strong as many people think.

According to a study published in JAMA Psychiatry, most people who use antidepressants only gain a small amount of weight over 12 months — for most medications, an increase of less than one percent of their original, pre-treatment body mass index (BMI).

Unlike other antidepressants, bupropion typically doesn’t cause weight gain. For example, in the study above, the researchers found that people who used bupropion experienced fluctuations of less than 0.25 percent of their original BMI over the course of 12 months of treatment.

Clinical trials of bupropion have also found that it typically doesn’t cause weight loss. In trials for Wellbutrin, a popular brand of bupropion, only 9.4 percent of people gained weight compared to 35 percent of people who received tricyclic antidepressants. Additionally, 28 percent of bupropion users actually lost more than five pounds.

Other studies have also found that bupropion causes mild weight loss when used over the long term.

In short, bupropion doesn’t appear to cause weight gain, at least not to the same extent as other common antidepressants. Most studies show the opposite — that bupropion either produces little change in weight or a small amount of weight loss.

Although uncommon, bupropion may cause a range of more serious adverse effects, including adverse reactions that may require medical attention. We’ve listed these below and provided information on each potential side effect, as well as what you can do if you’re affected.

Like other types of antidepressant medication, bupropion carries a “black box” warning from the FDA stating that it, as well as other medications in this category, may produce an increased risk of suicidal thoughts and behavior in children, adolescents and young adults.

Clinical trials of antidepressants do not show this risk in people over the age of twenty-four. Despite this, the FDA recommends monitoring for signs of suicidal thoughts or behavior in anyone prescribed an antidepressant.

This warning is common to antidepressants and also appears on the packaging of most SSRIs, SNRIs and other medications prescribed to treat depression and major depressive disorder. A less severe warning is used on the packaging of Zyban, a form of bupropion prescribed for smoking cessation.

If you experience suicidal thoughts, worsened depression or other abnormal thoughts after you start using bupropion, contact your healthcare provider as soon as you can. Call 911 if you think you are having a medical emergency.

Bupropion may cause seizures. Use of bupropion is associated with seizures in approximately 0.4 percent of people at typical dosages of 450mg or less per day, making this a rare side effect. Seizures are significantly more common at dosages higher than 450mg per day.

The risk of seizures in people using bupropion is dose-related and is typically higher in people with conditions such as bulimia or anorexia, people who have quit using certain drugs or alcohol recently and people affected by seizure disorders.

Other conditions, such as metabolic disorders, head injury, prescription drug use or illegal drug use, may also increase your risk of seizures while using bupropion.

Bupropion may contribute to an increase in blood pressure and hypertension (overly high blood pressure). Your healthcare provider may ask that you monitor your blood pressure periodically while using bupropion to stay aware of any increases or changes.

If you currently have hypertension, or have a history of cardiovascular health issues, your healthcare provider may adjust your dosage of bupropion, recommend careful monitoring of your blood pressure or prescribe a different medication.

Treatment with antidepressants such as bupropion is associated with an increased risk of manic and hypomanic episodes, particularly in people who have risk factors for bipolar disorder or who have been diagnosed with bipolar disorder.

Bupropion is currently not approved by the FDA for treating bipolar depression. If you have bipolar disorder or display risk factors for bipolar disorder, your healthcare provider may recommend using another type of medication to treat your symptoms.

There have been several reported cases of psychosis and other neuropsychiatric symptoms in patients treated with bupropion for depression. Several of these involved people who had previously used illicit drugs, while others involved patients diagnosed with bipolar disorder.

If you or a loved one experience any delusions, hallucinations, psychosis, paranoia, confusion or concentration disturbance while using bupropion, contact your healthcare provider.

Although rare, bupropion may cause anaphylactoid/anaphylactic reactions. If you develop any symptoms of an allergic reaction, such as hives, skin rash, shortness of breath, edema, pruritus (itchy skin) or chest pain, contact your healthcare provider.

Bupropion also may interact with other medications in ways that could cause some potential side effects.

If you’ve used monoamine oxidase inhibitors (MAOIs) within 14 days of starting bupropion, tell your healthcare immediately, as these drug interactions may be severe.

Potential drug interactions with bupropion also include other antidepressants like SSRIs, SNRIs and TCAs, as well as medications like antipsychotics, beta-blockers, blood thinners, corticosteroids and others.

As with other antidepressants, bupropion may cause withdrawal symptoms if you abruptly stop taking it as prescribed. This is known as antidepressant discontinuation syndrome, and is a common issue for people who suddenly end their usage of antidepressants.

Bupropion may be less likely to cause severe withdrawal symptoms than other antidepressants, such as SSRIs and SNRIs. However, if you’re prescribed bupropion and want to stop taking it, it’s still important to talk to your healthcare provider first.

To reduce your risk of experiencing bupropion withdrawal symptoms, your healthcare provider may recommend tapering your dosage gradually over time. We’ve explained this in more detail in our guide to bupropion withdrawal.

Bupropion can help in the treatment of depression and make it easier for you to deal with nicotine cravings while quitting smoking. Our full guide to bupropion goes into more detail on how this medication works, common dosages, frequently asked questions and more.

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With the sophisticated advancement these days, consumers find it more difficult to recognize genuine Nike shoes with the naked eye. Therefore, the question left is “How to check original Nike shoes?”. Let’s find out 3 ultimate ways we collected to identify the real and fake right now.

Among the many shoe companies out there, Nike is currently among the most recognizable. Nike is currently one of the most prominent shoe manufacturers in the world. This brand’s athletic footwear specializes in industry-leading comfort and stability features, combining with contemporary design elements with sporty silhouettes. As a result, Nike shoes are a favorite among athletes, fashionistas, and A-listers.

To get your hands on a pair of Nikes, however, you may have to pay a hefty amount. Therefore, when something becomes well-known but expensive, imitations often appear on the market. How do I know if Nikes are fake? In order to verify the shoes’ legitimacy, we refer to the following suggestions on how to check original Nike shoes. You can also check how to check original Adidas shoes here.

Nike’s genuine shoes always come with a separate design box for each shoe model, whether purchased in-store or online. Therefore, you can also quickly determine whether a product is genuine or counterfeit only based on its containers. It’s a first red flag if the seller sends you Nikes without the original packaging.

How to check original Nike shoes by inspecting the box?

Nike shoe boxes are typically made of high-quality hard paper with eye-catching colors and outstanding logos. The boxes come in a wide variety of colors and patterns, but the most common ones are orange, red, and brown. The barcode, style name, size, serial number and SKU (if applicable) should all be printed on the box.

How do I know if Nikes are fake? The counterfeit versions of these boxes often lack the identifying printed information that would alert consumers to the fraud. If you’re not sure whether or not the item comes with its original packaging and tags/labels, you should ask the seller. When you open the box of a genuine Nike shoe, you should see the accompanying accessories such as warranty paper, shoelaces, product tags, and so on.

However, keep in mind that some counterfeiters still often succeed in creating shoes and packaging that look remarkably like those of legitimate Nike stores. If that’s the case, don’t worry, we still have some other ways to distinguish them visibly.

Nike tweeted: “The shoe manufacturing date is located on the label sewn inside the shoe. Most of these labels are located on the tongue of the shoe.” Except for the Nike Free Rn and Nike Flyknit, most genuine Nike shoes have labels printed on the underside of the tongue. Therefore, you should check it carefully.

How to check if Nike shoes are original? Using your hands, you can see that genuine shoe tags are both tough and soft. It is usually light when illuminated under the light.

Through the stock-keeping unit (SKU) number

The SKU number on the interior labels should match the one on the box. The counterfeit Nike factories frequently attach sizing labels that are years out of date. An item manufactured in 2013 may have a label stating that it was designed in 2010, for instance. You can also check the official releasing date of that products as well. The fake may claim that they were created in 2008, whereas in reality, Nike produced them for the first time in 2010.

Each Nike shoe code typically consists of 9 digits or letters

Font – The words printed on genuine Nike shoe’s tags are sized and evenly separated, as shown in the image. The letter “C” in “CM” auth shoes is printed at a distance, whereas fake shoes are the inverse. Examine the word “e” in the phrase “Nikebetterworld.com” of authentic shoes, which has a pointed tail rather than the “e” usually printed on counterfeit shoes.

The line technique – If a straight line is drawn from the top of the logo’s peak down, it will pass through the words “T” and “E” in the phrase “Nikebetterworld.com” or “u” and “k” in the word UK, which are genuine Nike shoes. If not, you are most likely to purchase low-quality goods.

Check the serial number of Nike shoes

The serial number is used to identify genuine Nike shoes. Each Nike shoe code typically consists of 9 digits or letters, the first 6 of which are the shoe code and the next 3 of which are the color code of that shoe, for example, 667444 – 008. The code is located in the center, and you can use Google images to check the barcode as well.

The serial number on the tag should be identical to the number on the box

Cross-check the corresponding serial number to see if it is matched

You may not notice it, but all of Nike’s shoes are very uniform; it is difficult to find errors or only redundancy. The reason is simple: a high-quality pair of shoes will undoubtedly be subjected to stringent quality testing before release. The materials used in the production of world-famous brands are also of high quality. When there is any errors are detected that made it different from the other, up to a 90% chance that they may be counterfeit.

The words printed on genuine Nike shoe’s tags are sized and evenly separated

>> Read more: Japanese shoe size chart.

After knowing ​​how to check original Nike shoes through the products, it’s best, however, to check the stores you buy before even making an order. These days, buying shoes online is as natural as buying anything else online. There are still legitimate retailers who stock Nike products, but there will also always be a sizable market for cheap knockoffs. If you are planning to be in the market for some Nike gear, keep an eye out for these telltale signs to help you avoid buying counterfeits.

If you see a pair of Nike sneakers for a ridiculously low price on a website, you can be sure they are fake.  There are only two possible explanations for such a low price. They are either offering you previously owned shoes or knockoffs of the Nike brand. You can spend $60 or more on a pair of Nike shoes. Yet, buying new Nike shoes from a website that only offers them for $20 is probably not the best idea.

You can tell a lot about a shoe retailer by looking at the variety of footwear they have on their website. Copycat websites sell knockoffs of popular Nike shoes using photos that look real.

You can detect if a sneaker website is selling you authentic Nike shoes by looking at the product page and comparing it to the image of the shoes on Nike’s website.

If you’re seriously considering making a purchase, You may verify the vendor indeed possesses the Nike sneakers by asking him to take a selfie while wearing them. Asking the vendor to put a piece of paper with your name on it on top of the Nike shoes is a good alternative if he or she is unwilling to take a photo with you.

There are thousands of places to buy sneakers on the internet. Any online sneaker shop will likely carry the Nike shoes you’re looking for. Avoid any online store where customers have left negative feedback that includes the words “fake,” “rip-off,” “replica,” “knock-off,” or “imitation.”

Authentic pairs can be purchased from several official retailers, including Nike, Nordstrom, Foot Locker, and Zappos, however, they can be extremely pricey due to their original prices.

If you’re looking for authentic Nike footwear at a discount price, where should you go? Our top advice is to order a pair of authentic shoes online from a market with a strong reputation for strict policing the sale of fakes, like Japan. Through the Japanese domestic shopping website Janbox.com, customers from anywhere around the world can order Japanese shoes straight from Japan at Japanese domestic prices.