Double transgenic rats (dTGR), harboring human renin and. II (Ang II)–induced end-organ damage in double transgenic rats (dTGR). Untreated and relaxin-treated dTGR had similarly severe cardiac. In a separate survival study, levosimendan increased dTGR survival by. In dTGR, S18886 slightly lowered the blood pressure (162 +/- 15 vs.