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What is fgf23?


Asked By: Adhira Maharaj



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Medicos at Rajiv Gandhi University of Health Sciences Hospital Kansas City United States


Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. The FGF23 gene provides instructions for making a protein called fibroblast growth factor 23, which is produced in bone cells. Fibroblast growth factor 23 (FGF23) was identified as the last member of FGF family. Fibroblast growth factor 23 or FGF23 is a protein that in humans is encoded by the FGF23 gene. Fibroblast growth factor-23 (FGF23) is a bone-derived hormone suppressing phosphate reabsorption and vitamin D hormone synthesis in the. FGF23 targets organs, particularly the kidney, via an FGF receptor:Klotho complex that inhibits sodium-dependent phosphate uptake and 1α-hydroxylase activity.

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