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Crossmatching is a way for your healthcare provider to test your blood against a donor's blood to make sure they are fully compatible. In transfusion medicine, cross-matching or crossmatching is testing before a blood transfusion to determine if the donor's blood is compatible with the blood of. What is being tested? A crossmatch is a group of tests undertaken before a person requires a blood transfusion. The crossmatch is the final step of pretransfusion testing as a routine procedure. The crossmatch is the final step of pretransfusion testing as a routine procedure.