What is hmg coa?

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Adah Hora

, Television Production Assistant, Partnership Spelling

HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. β-Hydroxy β-methylglutaryl-CoA (HMG-CoA), also known as 3-hydroxy-3- methylglutaryl-CoA, is an intermediate in the mevalonate and ketogenesis pathways. HMG-CoA reductase is the rate-controlling enzyme of the mevalonate pathway, the metabolic pathway that produces cholesterol and other isoprenoids. HMG-CoA reductase catalyzes the nicotinamide adenine dinucleotide phosphate (NADPH)-dependent reduction of HMG-CoA to mevalonic acid (MVA in Figure 2). Thus, active HMG-CoA reductase enzyme accumulates in the endoplasmic reticulum in response to (1) a slow rate of degradation of the protein and (2) increased. HMG-CoA Reductase (or 3-hydroxy-3-methyl-glutaryl-CoA reductase or HMGR) is the rate-controlling enzyme of the mevalonate pathway, responsible for cholesterol and other isoprenoid biosynthesis.

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