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HMNT genotypes were successfully obtained in 116 and 122 control and AD subjects, respectively. Common factors that interfere with DAO and HMNT levels include many prescription drugs, for example: airway medications, such as theophylline. Histamine N-methyltransferase (HNMT, HMT) is an enzyme involved in the metabolism of histamine. HNMT genetic variants: Histamine n-methyltransferase (HMNT) is the enzyme that regulates histamine in the body via converting it from histamine. This week you have two assignments: a student-contributed resource ( Assignment 1) and a paper on access and community (Assignment 2). In the body, histamine is made from the amino acid histidine via decarboxylation.