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What is malt in immunology?

2 Answer(s) Available
Answer # 1 #

The lymphatic system is an organ system found in vertebrates that supports the immune system. The lymphatic system is made up of lymph vessels, lymph nodes, and other lymphoid tissues. Lymphoid tissues are the cells and organs that comprise the lymphatic system, including white blood cells, bone marrow, the thymus, spleen, and lymph nodes. Lymph vessels run parallel to the circulatory system, remove lymph from the blood, and carry it to the lymph nodes. Lymph nodes function to filter the lymph, removing harmful substances such as cancer cells and infections.

The mucosa-associated lymphoid tissues are a part of the lymphoid system and immune system. Since MALT are exposed to the external environment, the immune system devotes much of its resources to these tissues. Various adaptations enable MALT to protect the permeable mucosal membranes against harmful foreign substances they may come in contact with in the outside environment. For example, mucosal-associated lymphoid tissues have significantly higher concentrations of T-cells than other mucosal tissue. The T-cells function to directly attack pathogens. The general functions of MALT are to:

Mucosa-associated lymphatic tissue can be distinguished based on the level of tissue organization. MALT is generally organized into two broad categories: diffuse and organized. Diffuse MALT (D-MALT) are not anatomically independent masses. The tissue is diffused throughout a mucosal membrane and made up of mostly effector cells, immune cells that are temporary and activated in response to stimulation. D-MALT is found in the mucosal epithelium, intraepithelial leukocytes, and the lamina propria. In contrast, organized MALT (O-MALT) are anatomically independent masses of lymphatic tissue. O-MALT is found in the tonsils.

Mucosa-associated lymphoid tissues can be further organized based on where they are located within the body. MALT is found in the skin, eyes, nose, throat, gut, lungs, reproductive organs, stomach, and digestive tract. Different categories of MALT include:

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Answer # 2 #

The mucosa-associated lymphoid tissue (MALT) initiates immune responses to specific antigens encountered along all mucosal surfaces. MALT inductive sites are secondary immune tissues where antigen sampling occurs and immune responses are initiated.

Rikhav Bakshi