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What is ymdd mutation?


Asked By: Anika Guha



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Master's in Economics & Chinese (language), University of California, San Diego Process Improvement Test Cases Inventory Management Circuits Jacksonville United States


This mutation of the tyrosine-methionine-aspartate-aspartate (YMDD) motif in the C domain of the HBV DNA polymerase gene has also been associated with flares of liver disease (Dienstag et al. However, HBV species with mutations in the tyrosine-methionine-aspartate- aspartate (YMDD) locus of the HBV-RNA-dependent DNA polymerase confering. Hepatitis B virus (HBV) mutants with mutations in the YMDD motif of viral DNA polymerase/reverse transcriptase are described in patients infected with HBV who. The aim of this study was to detect the YMDD mutation responsible for lamivudine resistance in chronic hepatitis B virus (HBV)-infected patients. Background :YMDD motif variants of the hepatitis B virus (HBV) emerge in some chronic hepatitis B patients after prolonged lamivudine treatment. Long‑term LAM therapy may induce YMDD mutation and drug resistance.

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