Najmul Wirkud

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3,4-Methylenedioxyamphetamine (also known as MDA and sass) is an empathogen-entactogen, psychostimulant, and psychedelic drug of the amphetamine family that is encountered mainly as a recreational drug. In terms of pharmacology, MDA acts most importantly as a serotonin–norepinephrine–dopamine releasing agent (SNDRA). In most countries, the drug is a controlled substance and its possession and sale are illegal.

MDA is rarely sought after as a recreational drug compared to other drugs in the amphetamine family; however, it remains an important and widely used drug due to it being a primary metabolite, the product of hepatic N-dealkylation, of MDMA (ecstasy). In addition, it is common to find MDA as an adulterant of illicitly produced MDMA.

MDA currently has no accepted medical use.

MDA is bought, sold, and used as a recreational 'love drug', due to its enhancement of mood and empathy. A recreational dose of MDA is sometimes cited as being between 100 and 160 mg.

MDA produces serotonergic neurotoxic effects, thought to be activated by initial metabolism of MDA. In addition, MDA activates a response of the neuroglia, though this subsides after use.

Symptoms of acute toxicity may include agitation, sweating, increased blood pressure and heart rate, dramatic increase in body temperature, convulsions, and death. Death is usually caused by cardiac effects and subsequent hemorrhaging in the brain (stroke).

MDA is a substrate of the serotonin, norepinephrine, dopamine, and vesicular monoamine transporters, as well as a TAAR1 agonist, and for these reasons acts as a reuptake inhibitor and releasing agent of serotonin, norepinephrine, and dopamine (that is, it is an SNDRA). It is also an agonist of the serotonin 5-HT2A, 5-HT2B, and 5-HT2C receptors and shows affinity for the α2A-, α2B-, and α2C-adrenergic receptors and serotonin 5-HT1A and 5-HT7 receptors.

The (S)-optical isomer of MDA is more potent than the (R)-optical isomer as a psychostimulant, possessing greater affinity for the three monoamine transporters.

In terms of the subjective and behavioral effects of MDA, it is thought that serotonin release is required for its empathogen-entactogen effects, release of dopamine and norepinephrine is responsible for its psychostimulant effects, dopamine release is necessary for its euphoriant (rewarding and addictive) effects, and direct agonism of the serotonin 5-HT2A receptor is causative of its psychedelic effects.

The duration of the drug has been reported as about 6 to 8 hours.

MDA is a substituted methylenedioxylated phenethylamine and amphetamine derivative. In relation to other phenethylamines and amphetamines, it is the 3,4-methylenedioxy, α-methyl derivative of β-phenylethylamine, the 3,4-methylenedioxy derivative of amphetamine, and the N-desmethyl derivative of MDMA.

In addition to 3,4-methylenedioxyamphetamine, MDA is also known by other chemical synonyms such as the following:

MDA is typically synthesized from essential oils such as safrole or piperonal. Common approaches from these precursors include:

MDA may be quantitated in blood, plasma or urine to monitor for use, confirm a diagnosis of poisoning or assist in the forensic investigation of a traffic or other criminal violation or a sudden death. Some drug abuse screening programs rely on hair, saliva, or sweat as specimens. Most commercial amphetamine immunoassay screening tests cross-react significantly with MDA and major metabolites of MDMA, but chromatographic techniques can easily distinguish and separately measure each of these substances. The concentrations of MDA in the blood or urine of a person who has taken only MDMA are, in general, less than 10% those of the parent drug.

MDA constitutes part of the core structure of the β-adrenergic receptor agonist protokylol.

MDA was first synthesized by C. Mannich and W. Jacobsohn in 1910. It was first ingested in July 1930 by Gordon Alles who later licensed the drug to Smith, Kline & French. MDA was first used in animal tests in 1939, and human trials began in 1941 in the exploration of possible therapies for Parkinson's disease. From 1949 to 1957, more than 500 human subjects were given MDA in an investigation of its potential use as an antidepressant and/or anorectic by Smith, Kline & French. The United States Army also experimented with the drug, code named EA-1298, while working to develop a truth drug or incapacitating agent. Harold Blauer died in January 1953 after being intravenously injected, without his knowledge or consent, with 450 mg of the drug as part of Project MKUltra. MDA was patented as an ataractic by Smith, Kline & French in 1960, and as an anorectic under the trade name "Amphedoxamine" in 1961. MDA began to appear on the recreational drug scene around 1963 to 1964. It was then inexpensive and readily available as a research chemical from several scientific supply houses. Several researchers, including Claudio Naranjo and Richard Yensen, have explored MDA in the field of psychotherapy.

When MDA was under development as a potential pharmaceutical drug, it was given the international nonproprietary name (INN) of tenamfetamine.

MDA is schedule 9 prohibited substance under the Poisons Standards. A schedule 9 substance is listed as a "Substances which may be abused or misused, the manufacture, possession, sale or use of which should be prohibited by law except when required for medical or scientific research, or for analytical, teaching or training purposes with approval of Commonwealth and/or State or Territory Health Authorities."

MDA is a Schedule I controlled substance in the US.

In 2010, the ability of MDA to invoke mystical experiences and alter vision in healthy volunteers was studied. The study concluded that MDA is a "potential tool to investigate mystical experiences and visual perception".

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In the NFL, you don't get to choose who you play for... unless you do. It's rare when a player refuses to play for a franchise, especially by the one that drafted them. Often players will request trades, sign elsewhere in free agency or just play disgruntled.

There are a few cases where players just straight up refuse to play for the team. In recent years, this has become more of a trend when a player gets franchise tagged, such as Le'Veon Bell and Davante Adams' situations. Here are three NFL players who completely refused to play for a franchise:

John Elway was considered the best quarterback in the 1983 draft and he made it clear that he didn't want to play for the Baltimore Colts. The Colts held the first-overall pick in the draft. Elway and his father wanted to play closer to the West Coast.

Elway's refusal to play for the team lasted six days as he was traded to the Denver Broncos. In return, the Colts got quarterback Mark Hermann, offensive tackle Chris Hinton, and Denver’s 1984 first-round pick, which ended up being Ron Solt. Elway went on to win two Super Bowls with the Broncos.

Following the 2018 NFL season, Antonio Brown made it clear that he wanted Away from the Pittsburgh Steelers. On March 9, 2019, the Steelers agreed to trade Brown to the Oakland Raiders in exchange for a third- and fifth-round selection. The Steelers reportedly reached an agreement to send Brown to the Buffalo Bills before dealing him to Oakland.

The deal didn't go through because Brown refused to play for the Bills and called the news "fake news" on social media. This resulted in him being traded to the Raiders, where he never played a snap.

Eli Manning was drafted by the San Diego Chargers with the first-overall pick in the 2004 NFL draft. Manning was coveted as the number one quarterback coming out of Ole Miss. His father, Archie Manning said that he would refuse to play for the Chargers if drafted by them.

He was then traded to the New York Giants in exchange for rookie Phillip Rivers, a third-round pick, a 2005 first-round pick and a fifth-round pick. Manning winded up winning two Super Bowls with the Giants.

Generally, property sale agreements are executed under the following titles

Choose the right title for your agreement

The 1st line of agreement must have date and place of the agreement execution.

Seller’s name, age, address, and pan number

Buyer’s name, age, address, and pan number

Property schedule is the description of the property. Generally, a property schedule has three sub-schedule. They are schedule A, Schedule B, and Schedule C

Schedule A: Land conversion details (from agricultural to residential). Land survey number and measurement of the land where this apartment is built

Schedule B: Area of undivided land share

Schedule C: Super buildup, build up, and carpet area of your flat

Details of how seller acquired the property. Details include mother deed registration number, date, Khata and property tax ID.

Payment terms in figures and words, Mode of payment

Beneficiary name, bank account number, bank name, transaction numbers, and date of transaction.

Tentative date of sale deed registration. The seller or his GPA holder should agree to execute the Sale Deed in favour of the buyer.

Seller obtains “No Objection Certificate” (NoC) from Bank, society office. Seller pays NOC-related charges to Apartment Association and obtains NOC before the registration of deed of sale

Seller conveys the Schedule Property free from all encumbrances, attachments, court proceedings

Seller pays any maintenance charges, water charges, electricity bills, and any other bills raised against the scheduled property by the Resident’s Welfares Association until the date of registration of sale deed.

The buyer or his nominees shall bear the stamp duty and registration charges and other incidental charges in respect of the sale deed for the Schedule Property.

The seller should confirm that they have not entered into any agreement or GPA with any other person or persons prior to your sale agreement

In case of delay in delivery of possession, seller shall pay 18% interest on net amount paid by buyer, for the duration for delay

Seller should produce up-to-date property tax and any other relevant documents for the purpose of registration of sale deed as demanded by the Sub Registrar and also produce all the original documents at the time of Registration.

if any side decides to retract from property transaction and does not make payments or execute the documents, they will be liable for a penalty of an amount of Rs. 2,00,000/- (approx figure)

Specifically, if the seller back out from the transaction, the seller shall return all payments received as advance (including TDS paid by buyer, if any) and also pay Rs. 2,00,000/- as penalty.

If buyer backs out or does not complete the entire transaction in the timelines envisaged, provided the seller provides all necessary documents, The buyer will forfeit Rs. 2,00,000/- as penalty.

In case of mutual termination, all payments (without any interest) from either side should be completed within 15 days.

Seller should deliver the vacant possession and all the original title deeds of the Schedule Property to the PURCHASER after payment of balance sale consideration amount and at the time of registration and execution of the Sale Deed. The documents include mother deed, tax paid receipt, occupation certificate and khata.

The parties herein should mutually co-operate in smooth implementation of the terms and conditions of this Agreement of Sale.

Jurisdiction of court in case of dispute.

In Bangalore, we provide end-to-end assistance for sale agreement execution. Our service includes drafting + execution + franking + home delivered in 3 working days.

To opt for our service, please write to us pgnproperties@gmail.com or whatsapp to +91-97424 79020.

Thank you for reading….