Why is pdc most active in the mitochondria?

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Ferrier, D. R., ed. Lippincott Illustrated Reviews: Biochemistry, 7th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2017, Chapter 6: Bioenergetics and Oxidative Phosphorylation: Section V, VI, Chapter 8: Introduction to Metabolism and Glycolysis, Chapter 9: TCA Cycle and Pyruvate Dehydrogenase Complex: Section IIA, IIB, Chapter 11: Glycogen Metabolism: Section V, VI, Chapter 16: Fatty Acid Ketone Body and TAG Metabolism: Section II, IV, V, Chapter 23: Metabolic Effect of Insulin and Glucagon, Chapter 25: Diabetes Mellitus.

Le, T., and V. Bhushan. First Aid for the USMLE Step 1, 29th ed. New York: McGraw Hill Education, 2018, 72–78, 85–89.

Lieberman, M., and A. Peet, eds. Marks' Basic Medical Biochemistry: A Clinical Approach, 5th ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 2018, Chapter 2: The Fed or Absorptive State, Chapter 19: Basic Concepts of Regulation: Section IV.A.1.2, Chapter 20: Cellular Bioenergetics, Chapter 22: Generation of ATP from Glucose: Section I.A.B.C, III, Chapter 24: Oxidative Phosphorylation and the ETC: Section I.E, II, III, Chapter 31: Synthesis of Fatty Acids: Section I.A.B, IV, V.

Figures

Grey, Kindred, Figure 4.1 Summary of glycolysis... 2021. https://archive.org/details/4.1_20210924. CC BY 4.0.

Grey, Kindred, Figure 4.2 Regulatory step committed by hexo or glucokinase... 2021. https://archive.org/details/4.2_20210924. CC BY 4.0.

Grey, Kindred, Figure 4.4 Regulation of glucokinase by glucokinase regulatory protein. 2021. https://archive.org/details/4.4_20210924. CC BY 4.0. Added ion channel by Léa Lortal from Noun Project and sphere by Pablo Rozenberg from Noun Project.

Grey, Kindred, Figure 4.5 Regulation of PFK1 by fructose 2,6-bisphosphate generated by PFK2. 2021. https://archive.org/details/4.5-new. CC BY 4.0.

Grey, Kindred, Figure 4.6 Regulation of pyruvate kinase phosphorylation and fructose 1,6-bisphosphate. 2021. https://archive.org/details/4.6-new. CC BY 4.0.

Grey, Kindred, Figure 4.7 Glycerol 3-phosphate shuttle. 2021. https://archive.org/details/4.7_20210924. CC BY 4.0. Added ion channel by Léa Lortal from the Noun Project.

Grey, Kindred, Figure 4.8 Malate-aspartate shuttle. 2021. https://archive.org/details/4.8_20210924. CC BY 4.0.

Lieberman M, Peet A. Figure 4.3 Comparison of glucokinase and hexokinase kinetics. Adapted under Fair Use from Marks' Basic Medical Biochemistry. 5th Ed. pp 154. Figure 9.4 A comparison between hexokinase I and glucokinase. 2017.